Nicotine chewing-gum.

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Randomised controlled trial of nicotine chewing-gum.

The effectiveness of 2 mg nicotine chewing-gum as an aid to stopping smoking was compared with a placebo containing 1 mg nicotine, but unbuffered, in a double-blind randomised trial. Of 58 subjects given the active gum, 27 (47%) were not smoking at one-year follow-up compared with 12 (21%) of the 58 subjects treated with placebo (p less than 0.025). By the most stringent criterion of outcome, 1...

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Plasma nicotine levels after cigarette smoking and chewing nicotine gum.

Plasma nicotine levels were measured over seven hours of smoking cigarettes (1-2 mg nicotine) in a single subject under standardised conditions, and were compared with the levels obtained from chewing-gum containing either 2 mg or 4 mg nicotine. Levels comparable to those resulting from smoking were not obtained with the 2-mg gum, but peak levels on the 4-mg gum averaged 40-1 ng/ml from the thi...

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Placebo controlled trial of nicotine chewing gum in general practice.

Of 2110 adult cigarette smokers originally recruited to a study of the effect of antismoking advice in general practice, 429 who reported at follow up after one year that they had tried unsuccessfully to stop smoking were offered "a special antismoking chewing gum," either nicotine gum or a placebo gum, in a double blind study. Of 200 who were willing to try the gum, 101 were randomly allocated...

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Theoretical background and clinical use of nicotine chewing gum.

In our view, nicotine chewing gum is the most significant single advance achieved so far in the whole field of smoking cessation. It is the only treatment that has yet been shown to have a specific effect over and above that of attention-placebo factors, and this has been demonstrated repeatedly by several research groups in different countries. It is suitable for use as an adjunct both to inte...

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Influence of nicotine chewing gum on fetal blood flow.

Several studies have shown that smoking is not beneficial to the fetus. Among the acute effects, influence on fetal circulation has been reported. Nicotine is considered to be one of the active agents in cigarette smoke. To test the nicotine effects on the human fetus, maternal and fetal cardiovascular dynamics were studied in 20 pregnant women when chewing a chewing gum containing 4 mg of nico...

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ژورنال

عنوان ژورنال: BMJ

سال: 1982

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.285.6344.811-a